Back to Search Start Over

Prevalence and outcome of pre-onset frailty in patients with acute stroke.

Authors :
Iwasawa, Tatsuya
Aoyagi, Yoichiro
Suda, Satoshi
Ishiyama, Daisuke
Toi, Kennosuke
Ohashi, Miho
Kimura, Kazumi
Source :
Topics in Stroke Rehabilitation; Jul2024, Vol. 31 Issue 5, p493-500, 8p
Publication Year :
2024

Abstract

Frailty in older individuals is an underappreciated condition that affects the incidence and/or prognosis of stroke. We evaluated the prevalence of pre-onset frailty in patients with acute first-onset and recurrent strokes and association between pre-onset frailty and functional disability at hospital discharge. This prospective cohort study included 210 acute stroke patients admitted to the Stroke Unit of Nippon Medical School Hospital during November 2021–June 2022. The mean participant age was 79.2 ± 7.4 years. Age, sex, pre-onset frailty, body mass index (BMI), stroke type, medical history, and National Institutes of Health Stroke Scale (NIHSS) score at admission were evaluated. Frailty was defined as a clinical frailty scale (CFS) score ≥ 5. Frailty prevalence was calculated for all patients, and scores of functional disabilities at discharge were evaluated using modified Rankin scale. Overall frailty prevalence was 31% in all stroke patients, with 24% and 47% of first-onset and recurrent strokes, respectively. Pre-onset frailty, NIHSS score at admission, age, stroke type, previous stroke, sex, BMI, dyslipidemia, and atrial fibrillation were significantly associated with functional disability at discharge. Logistic regression analysis revealed that CFS score, NIHSS score at admission, and previous stroke were independent predictors of functional disability at discharge. Approximately one-fourth of patients with first-onset stroke had pre-onset frailty; the rate doubled in recurrent stroke; these rates appear to be much larger than rate in healthy individuals. Pre-onset frailty, a negative independent factor affecting functional disability at discharge, is important for pre-onset frailty evaluation and rehabilitation intervention in acute stroke patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10749357
Volume :
31
Issue :
5
Database :
Supplemental Index
Journal :
Topics in Stroke Rehabilitation
Publication Type :
Academic Journal
Accession number :
177520295
Full Text :
https://doi.org/10.1080/10749357.2023.2291898