Data from University of Milan Provide New Insights into Carcinoid Tumor (Head-to-head: Should Ki67 Proliferation Index Be Included In the Formal Classification of Pulmonary Neuroendocrine Neoplasms?).

A report from the University of Milan discusses the classification of lung neuroendocrine neoplasms (NENs) based on the 2021 World Health Organization (WHO) guidelines. The report explores the inclusion of the Ki67 proliferation index as a criterion for distinguishing between low- to intermediate-grade neuroendocrine tumors (NETs) and high-grade neuroendocrine carcinomas (NECs). The use of the Ki67 marker in the classification and clinical practice of these neoplasms is a topic of ongoing debate. The research provides a detailed discussion of the arguments for and against incorporating the Ki67 proliferation index in the formal classification of pulmonary neuroendocrine neoplasms. [Extracted from the article]