HPV-ASSOCIATED SEVERE DYSPLASIA IN A HIV-POSITIVE PATIENT: CASE REPORT.

A 51-year-old female patient, who is HIV-positive, was referred for the assessment of a white lesion on the buccal mucosa on the left side, near the labial commissure. The lesion measured approximately 2 cm and had well-defined, verrucous surfaces, encircled by a brownish halo, indicative of melanin pigmentation. An incisional biopsy was conducted, and the histopathological examination revealed squamous epithelium with hyperkeratosis, acanthosis, and severe epithelial dysplasia. Furthermore, superficial cells displayed koilocytosis, indicating a viral infection. Immunohistochemistry for p16 demonstrated widespread nuclear and cytoplasmic positivity in the surface epithelium. In situ hybridization for broad-spectrum HPV detected viral DNA within the nucleus of epithelial cells. These findings led to the diagnosis of HPV-associated severe epithelial dysplasia. The patient was referred to a head and neck surgeon, and a complete resection of the lesion was performed. The patient is currently under observation and shows no clinical signs of recurrence. [ABSTRACT FROM AUTHOR]