Healthy human induced pluripotent stem cell-derived cardiomyocytes exhibit sex dimorphism even without the addition of hormones.

A preprint abstract from biorxiv.org discusses the potential sex differences in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and the importance of considering sex as a variable in in vitro studies. The study generated three female and three male hiPSC-lines to study sex differences in cardiac models. The results showed enhanced calcium handling in female-derived hiPSC-CM compared to male, and over 300 differentially expressed genes between the two sexes. The findings suggest that sex should be considered as a variable in studies related to cardiomyocyte function and cardiac health. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]