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Studies from Central Washington University in the Area of Obesity, Fitness and Wellness Reported (Revisiting the 1,3-azadiene-succinic Anhydride Annulation Reaction for the Stereocontrolled Synthesis of Allylic 2-oxopyrrolidines Bearing Up To...).
- Source :
- Drug Week; 6/21/2024, p2999-2999, 1p
- Publication Year :
- 2024
-
Abstract
- A report from Central Washington University discusses research on the synthesis of allylic 2-oxopyrrolidines, which are important components of certain pharmaceuticals. The researchers describe a flexible annulation strategy that combines succinic anhydride and 1,3-azadienes to produce these compounds. The approach is chemoselective, efficient, modular, scalable, and diastereoselective, allowing for post-diversification and the incorporation of motifs with pharmaceutical value. The research concludes that this strategy is a flexible and effective method for producing allylic 2-pyrrolidinones with contiguous stereocenters. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 15316440
- Database :
- Supplemental Index
- Journal :
- Drug Week
- Publication Type :
- Periodical
- Accession number :
- 177867866