Natural products for the treatment of age-related macular degeneration.

• The pathogenesis of AMD is related to oxidative stress, chronic Inflammation, and neovascularization. • Bioactive products from herbal medicines and functional foods may help AMD patients by alleviating oxidative stress, treating chronic inflammation, and slowing the development of new blood vessels. • Research is needed to understand the effects, safety and efficacy in investigating the translational potential of NP- Bench to bedside. • Mutiple new methods can be used in NP-related drug investigation. • Natural plant products may represent a promising direction for the development of novel drugs in the treatment of AMD. Age-related macular degeneration (AMD) is a chronic retinal disease that significantly influences the vision of the elderly. There is no effective treatment and prevention method. The pathogenic process behind AMD is complex, including oxidative stress, inflammation, and neovascularization. It has been demonstrated that several natural products can be used to manage AMD, but systematic summaries are lacking. PubMed, Web of Science, and ClinicalTrials.gov were searched using the keywords "Biological Products" AND "Macular Degeneration" for studies published within the last decade until May 2023 to summarize the latest findings on the prevention and treatment of age-related macular degeneration through the herbal medicines and functional foods. The eligible studies were screened, and the relevant information about the therapeutic action and mechanism of natural products used to treat AMD was extracted. Our findings demonstrate that natural substances, including retinol, phenols, and other natural products, prevent the development of new blood vessels and protect the retina from oxidative stress in cells and animal models. However, they have barely been examined in clinical studies. Natural products could be highly prospective candidate drugs used to treat AMD, and further preclinical and clinical research is required to validate it to control the disease. [Display omitted] [ABSTRACT FROM AUTHOR]