Researchers' Work from West Virginia University Focuses on Experimental Autoimmune Encephalomyelitis (Myelin oligodendrocyte glycoprotein reactive Th17 cells drive Janus Kinase 1 dependent transcriptional reprogramming in astrocytes and alter...).

A study conducted at West Virginia University focused on experimental autoimmune encephalomyelitis (EAE), an autoimmune demyelinating disease that affects the central nervous system. The researchers examined the impact of pathogenic Th17 cells on astrocytes, a type of glial cell in the CNS. They found that Th17 cells reprogrammed astrocytes by driving transcriptomic changes through a Janus Kinase (JAK)1-dependent mechanism. This study provides evidence of Th17 cell reprogramming of astrocytes, which may contribute to changes in astrocytic responsiveness to cytokines during autoimmune neuroinflammation. [Extracted from the article]