Study Findings from State University of Campinas (UNICAMP) Provide New Insights into Aspergillus fumigatus (Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus).

A recent study conducted by researchers at the State University of Campinas (UNICAMP) has provided new insights into Aspergillus fumigatus, a human pathogenic fungus that poses a public health problem. The study focused on the role of sirtuins, NAD+-dependent lysine deacetylases, in A. fumigatus. The researchers found that the deletion of a specific sirtuin gene, SirE, resulted in significant changes in gene expression and protein acetylation, as well as a decrease in virulence. These findings suggest that sirtuin inhibitors could be potential therapeutic strategies for combating A. fumigatus infections, either alone or in combination with existing antifungal drugs. [Extracted from the article]