Researchers from University of South China Provide Details of New Studies and Findings in the Area of Methicillin-Resistant Staphylococcus aureus [Novel Natural Osthole-inspired Amphiphiles As Membrane Targeting Antibacterials Against...].

Researchers from the University of South China have developed a series of novel osthole amphiphiles that show promise as antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA). These amphiphiles demonstrated strong inhibitory effects on S. aureus and 10 clinical MRSA isolates, with comparable efficacy to the commercial antibiotic vancomycin. The amphiphiles also exhibited rapid bacteria killing, low toxicity, good membrane selectivity, and good plasma stability. In vivo studies showed that the amphiphile 6aa had strong anti-MRSA efficacy and reduced MRSA-induced proinflammatory cytokines. This research suggests that the osthole-inspired amphiphiles could be potential candidates for treating MRSA infections. [Extracted from the article]