New Pathology and Laboratory Medicine Study Findings Reported from Boston Children's Hospital (Principles of Analytic Validation of Immunohistochemical Assays).

A recent study conducted at Boston Children's Hospital provides updated recommendations for the analytic validation of immunohistochemical assays. The study aimed to assess new evidence and modify existing guidelines accordingly. The updated recommendations include guidance on the validation of assays with distinct scoring systems and the verification of US Food and Drug Administration approved/cleared assays. Additionally, specific guidance is offered for validating immunohistochemistry performed on cytology specimens. The study concludes that while many of the original guideline statements remain similar, the new recommendations address important areas of concern. [Extracted from the article]