Chinese Academy of Medical Sciences Researchers Broaden Understanding of Acne Vulgaris (Inflammatory loop involving Staphylococcus aureus, IL-36g, and cathepsin S drives immunity disorders in familial acne inversa keratinocytes).

Researchers from the Chinese Academy of Medical Sciences have conducted a study on acne vulgaris, specifically focusing on the interaction between bacteria and keratinocytes in the pathophysiology of acne inversa (AI). The study found that the dysregulated bacterial-host immune interactions play a crucial role in AI, and the NCSTN gene is associated with AI. The researchers discovered that the impairment of the NCSTN/MEK/ERK axis, in conjunction with Staphylococcus aureus, promotes IL-36g production and subsequent inflammation in keratinocytes. The study suggests a synergistic relationship between S. aureus and the NCSTN/MAPK/KLF4 axis in familial AI keratinocytes. [Extracted from the article]