Findings in Staphylococcus aureus Reported from Chapman University School of Pharmacy (Mechanistic Study of Antimicrobial Effectiveness of Cyclic Amphipathic Peptide [R [ [4] ] W [ [4] ] ] against Methicillin-Resistant Staphylococcus...).

A recent study conducted by researchers at Chapman University School of Pharmacy explored the antimicrobial effectiveness of a cyclic amphipathic peptide called [R [ [4] ] W [ [4] ] ] against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli). The study found that [R [ [4] ] W [ [4] ] ] exhibited bactericidal activity against bacterial isolates, with a synergistic effect with gentamicin against E. coli but not against MRSA. The researchers also investigated the mechanism of action of [R [ [4] ] W [ [4] ] ] against MRSA and found that it interacts with bacterial cell membranes, causing concentration-dependent membrane perturbation. The study suggests that [R [ [4] ] W [ [4] ] ] may be a potential antimicrobial peptide worth further consideration. [Extracted from the article]