Reports on Breast Cancer Findings from Al Zaytoonah University Jordan Provide New Insights (Glutathione and Xanthine Metabolic Changes In Tamoxifen Resistant Breast Cancer Cell Lines Are Mediated By Down-regulation of Gss and Xdh and Correlated...).

A recent study conducted at Al Zaytoonah University in Jordan explored the metabolic changes in tamoxifen-resistant breast cancer cell lines. The researchers used metabolic profiling and gene expression analysis to identify potential biomarkers of resistance and understand the underlying molecular mechanisms. The study found that tamoxifen-resistant cells exhibited increased levels of glutamine, taurine, glutathione, and xanthine, as well as decreased levels of certain amino acids. Additionally, the expression of genes encoding key enzymes involved in these metabolic pathways was altered. The findings provide insights into the development of resistance and may contribute to the development of new treatment strategies. [Extracted from the article]