Association of Depression With the Progression of Multimorbidity in Older Adults: A Population-Based Cohort Study.

• What is the primary question addressed by this study? Can depression influence the progression of multimorbidity in community-dwelling older adults? • What is the main finding of this study? This prospective cohort study found that late-life depression was associated with a more rapid progression of multimorbidity and the risk of developing highly complex multimorbidity. This association might be pronounced when depression was severe or anhedonic. • What is the meaning of the finding? Additional investigation is required to ascertain if managing depression can mitigate the development of multimorbidity in older adults. The relationship between depression and the risk of multimorbidity progression has rarely been studied in older adults. This study was aimed to determine whether depression is associated with progression in the severity and complexity of multimorbidity, considering the influence of depression's severity and subtype. As a part of the Korean Longitudinal Study on Cognitive Aging and Dementia, this population-based cohort study followed a random sample of community-dwelling Koreans aged 60 and older for 8 years at 2-year intervals starting in 2010. Participants included those who completed mood and multimorbidity assessments and did not exhibit complex multimorbidity at the study's outset. Depression was assessed using the Geriatric Depression Scale, while multimorbidity was evaluated using the Cumulative Illness Rating Scale. The study quantified multimorbidity complexity by counting affected body systems and measured multimorbidity severity by averaging scores across 14 body systems. The 2,486 participants (age = 69.1 ± 6.5 years, 57.6% women) were followed for 5.9 ± 2.4 years. Linear mixed models revealed that participants with depression had a faster increase in multimorbidity complexity score (β =.065, SE = 0.019, p = 0.001) than those without depression, but a comparable increase in multimorbidity severity score (β =.001, SE =.009, p = 0.870) to those without depression. Cox proportional hazard models revealed that depression was associated with the risk of developing highly complex multimorbidity affecting five or more body systems, particularly in severe or anhedonic depression. Depression was associated with the worsening of multimorbidity in Korean older adults, particularly when severe or anhedonic. Early screening and management of depression may help to reduce the burden of multimorbidity in older adults. [ABSTRACT FROM AUTHOR]