Back to Search
Start Over
Salivary gland carcinosarcoma ex pleomorphic adenoma: a case report with molecular characterization.
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology; Aug2024, Vol. 138 Issue 2, p301-305, 5p
- Publication Year :
- 2024
-
Abstract
- True malignant mixed tumors, also known as salivary gland carcinosarcoma (SCS), are uncommon yet highly aggressive lesions associated with a poor prognosis. These tumors exhibit a distinctive biphasic structure characterized by both epithelial and mesenchymal components. Recent research has shown that the majority of SCS cases stem from pre-existing pleomorphic adenomas (PAs), suggesting a stepwise developmental pattern. In this report, we present a case of a 73-year-old female with SCS and describe the clinical, radiographic, and pathologic observations. Notably, the SCS was associated with a residual PA. The SCS displayed a CTNNB1::PLAG1 gene rearrangement, providing a molecular basis for its origin from the PA. Further DNA genomic analysis exposed mutations in BAP1, PER1, and LRPB1. Our findings provide support to the theory that SCS emerges from a pre-existing PA while highlighting the multiple genetic changes that could contribute to malignant transformation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 22124403
- Volume :
- 138
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology & Oral Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 178425876
- Full Text :
- https://doi.org/10.1016/j.oooo.2024.02.030