Data on Brain Ischemia Detailed by Researchers at Capital Medical University [Atf5-mediated Mitochondrial Unfolded Protein Response (Uprmt) Protects Neurons Against Oxygen-glucose Deprivation and Cerebral Ischemia].

Researchers at Capital Medical University in Beijing, China have investigated the potential therapeutic effects of the mitochondrial unfolded protein response (UPRmt) on ischemic stroke. They conducted experiments using in vivo and in vitro models of ischemic stroke and found that inducing UPRmt protected neurons against oxygen-glucose deprivation. They also discovered that meclizine, an FDA-approved drug, triggered UPRmt and provided neuroprotection. In a mouse model of cerebral ischemia, pretreatment with meclizine reduced infarction and improved neurological outcomes. These findings suggest that UPRmt could be a promising therapeutic target for ischemic stroke. [Extracted from the article]