Maytenhoiridosides A and B, two new iridoid glycosides from the branches of Maytenus hookeri.

Two new iridoid glycosides, maytenhoiridosides A (1) and maytenhoiridosides B (2), along with three known compounds (3 – 5), were isolated from the branches of Maytenus hookeri. Their chemical structures were elucidated by HR-ESI-MS, 1D and 2D-NMR spectra, acid hydrolysis analysis, and comparison with literature data. Among the isolated compounds, compound 5 exhibited significant cytotoxic activity against the HCT-116, SKOV3 and SK-Hep-1 cells, with IC 50 values of 9.49±1.40, 34.66±1.48 and 12.66±3.32 µM, respectively, while the others showed weak or no activity at 50 μM. [Display omitted] • Two new iridoid glycosides were isolated from Maytenus hookeri. • The structures were confirmed by extensive spectroscopic analyses. • Compound 5 exhibited significant cytotoxic activities. [ABSTRACT FROM AUTHOR]