First Affiliated Hospital of Wenzhou Medical University Researchers Add New Data to Research in Experimental Autoimmune Hepatitis (FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune...).

Researchers from the First Affiliated Hospital of Wenzhou Medical University have conducted a study on experimental autoimmune hepatitis (AIH) and its potential treatment options. The study focused on the role of fibroblast growth factor 4 (FGF4) in regulating M1 macrophages and reducing liver inflammation in AIH. The researchers found that FGF4 treatment activated the PI3K-AKT signaling pathway in macrophages, leading to a reduction in M1 macrophages and hepatic inflammation. This study suggests that FGF4 may be a novel target for treating inflammation in patients with AIH. [Extracted from the article]