New Obesity and Diabetes Findings from University Hospital Discussed (Hypertriglyceridemia Results From an Impaired Catabolism of Triglyceride-rich Lipoproteins In plin1-related Lipodystrophy).

Researchers from the University Hospital in Dijon, France have conducted a study on the mechanisms of hypertriglyceridemia associated with PLIN1-related familial partial lipodystrophy (FPL). The study found that patients with PLIN1-related FPL had decreased fat mass, insulin resistance, and diabetes, as well as higher plasma triglyceride levels compared to healthy controls and patients with type 2 diabetes. The researchers discovered that the hypertriglyceridemia in PLIN1-related FPL is a result of a decrease in the catabolism of triglyceride-rich lipoproteins, which may be due to a reduction in lipoprotein lipase availability related to decreased adipose tissue mass. This research provides insights into the understanding of obesity and diabetes. [Extracted from the article]