Studies from National University Further Understanding of Cholestasis (Tauroursodeoxycholate Prevents Estradiol 178-d-glucuronide-induced Cholestasis and Endocytosis of Canalicular Transporters By Switching Off Pro-cholestatic Signaling Pathways).

A study conducted at the National University in Rosario, Argentina, explores the effects of tauroursodeoxycholate (TUDC) on cholestasis induced by estradiol 178-d-glucuronide (E 2 17G). Cholestasis is characterized by the impaired function and localization of canalicular transporters Bsep and Mrp2. The study found that TUDC can prevent the endocytosis of these transporters by inhibiting cPKC and PI3K/Akt activation. TUDC restores the function and localization of Bsep and Mrp2, providing a potential treatment option for cholestasis. [Extracted from the article]