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Glyburide confers neuroprotection against age-related macular degeneration (AMD).
- Source :
- Translational Research: The Journal of Laboratory & Clinical Medicine; Oct2024, Vol. 272, p81-94, 14p
- Publication Year :
- 2024
-
Abstract
- Glyburide, a sulfonylurea drug used to treat type 2 diabetes, boasts neuroprotective effects by targeting the sulfonylurea receptor 1 (SUR1) and associated ion channels in various cell types, including those in the central nervous system and the retina. Previously, we demonstrated that glyburide therapy improved retinal function and structure in a rat model of diabetic retinopathy. In the present study, we explore the application of glyburide in non-neovascular ("dry") age-related macular degeneration (AMD), another progressive disease characterized by oxidative stress-induced damage and neuroinflammation that trigger cell death in the retina. We show that glyburide administration to a human cone cell line confers protection against oxidative stress, inflammasome activation, and apoptosis. To corroborate our in vitro results, we also conducted a case-control study, controlling for AMD risk factors and other diabetes medications. It showed that glyburide use in patients reduces the odds of new-onset dry AMD. A positive dose-response relationship is observed from this analysis, in which higher cumulative doses of glyburide further reduce the odds of new-onset dry AMD. In the quest for novel therapies for AMD, glyburide emerges as a promising repurposable drug given its known safety profile. The results from this study provide insights into the multifaceted actions of glyburide and its potential as a neuroprotective agent for retinal diseases; however, further preclinical and clinical studies are needed to validate its therapeutic potential in the context of degenerative retinal disorders such as AMD. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19315244
- Volume :
- 272
- Database :
- Supplemental Index
- Journal :
- Translational Research: The Journal of Laboratory & Clinical Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 179465482
- Full Text :
- https://doi.org/10.1016/j.trsl.2024.05.002