Uniformed Services University of the Health Sciences Researcher Describes Research in Acute Kidney Injury (Canagliflozin Mitigates Acute Kidney Injury Secondary to Resuscitative Endovascular Balloon Occlusion of the Aorta in a Porcine Model of...).

A recent study conducted by researchers at the Uniformed Services University of the Health Sciences in Bethesda, Maryland, explored the potential of using canagliflozin, a medication commonly used to treat diabetes and heart failure, to mitigate acute kidney injury (AKI) and reduce inflammation in a swine model of severe renal ischemia reperfusion injury (IRI) induced by hemorrhage and aortic occlusion. The study found that a single dose of canagliflozin administered shortly after the ischemic insult resulted in less severe AKI, improved renal function, reduced proteinuria, and lower levels of the pro-inflammatory cytokine IL-6. These findings suggest a potential therapeutic role for canagliflozin in mitigating the effects of renal IRI and warrant further investigation. [Extracted from the article]