Findings on Acute Kidney Injury Detailed by Investigators at Nanjing Medical University (Mitochondrial Pyruvate Carrier 2 Mitigates Acute Kidney Injury Via Sustaining Mitochondrial Metabolism).

A recent report from Nanjing Medical University in China discusses the potential for mitigating acute kidney injury (AKI) caused by the chemotherapeutic drug cisplatin. The researchers found that a reduction in the expression of mitochondrial pyruvate carrier 2 (MPC2) was associated with cisplatin-induced AKI. However, overexpression of MPC2 was able to attenuate nephrotoxicity by restoring pyruvate metabolism and mitochondrial function. The study suggests that targeting the MPC2-pyruvate metabolism axis could be a promising strategy for alleviating AKI induced by cisplatin. [Extracted from the article]