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Pro-resolving metabolites: Future of the fish oil supplements.

Authors :
Maliha, Asma
Tahsin, Maisha
Fabia, Tayeba Zaman
Rahman, Shaikh Mizanoor
Rahman, Md Mizanur
Source :
Journal of Functional Foods; Oct2024, Vol. 121, pN.PAG-N.PAG, 1p
Publication Year :
2024

Abstract

[Display omitted] • SPMs actively resolve inflammation and repair tissue better than Omega-3 fatty acids. • SPMs are more potent than omega-3s due to their direct involvement in inflammation regulation. • Clinical trials and preclinical studies have shown that SPMs are more effective. • SPMs directly modulate inflammatory pathways through specific receptors. • SPMs are effective at lower therapeutic dosages compared to omega-3 fatty acids. Specialized pro-resolving mediators (SPMs) derived from omega-3 fatty acids have emerged as promising therapeutic agents for managing inflammatory diseases. This comprehensive review examines the role of SPMs in inflammation resolution and tissue repair across various disease conditions, including neurodegenerative diseases, cardiovascular diseases, musculoskeletal disorders, diabetes, and cancer. We discuss the diverse metabolic pathways involved in the biosynthesis of SPMs, their mechanisms of action, and their effects on immune cell function and inflammatory signaling pathways. Clinical trials and preclinical studies demonstrating the efficacy of SPMs in reducing inflammation and improving patient outcomes are summarized. Therapeutic dosages of SPMs are compared to their precursors. Challenges associated with determining optimal dosages, factors influencing metabolic efficiency, and the development of nanoparticle drug delivery systems for SPMs are also discussed. Despite the progress made, further research is needed to optimize SPM therapies and address remaining challenges for clinical translation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17564646
Volume :
121
Database :
Supplemental Index
Journal :
Journal of Functional Foods
Publication Type :
Academic Journal
Accession number :
179734214
Full Text :
https://doi.org/10.1016/j.jff.2024.106439