Findings in Cisplatin Therapy Reported from Lomonosov Moscow State University (Cisplatin Resistance and Metabolism: Simplification of Complexity).

A recent report from Lomonosov Moscow State University discusses the challenges of cisplatin therapy, a well-known anti-cancer drug. The development of resistance to cisplatin is a major obstacle to its effectiveness, and this resistance is often linked to metabolic changes in cancer cells. The report explores the disruptions in glucose, lipid, and amino acid metabolism in cisplatin-resistant cells, as well as the roles of ferroptosis and autophagy in acquiring this drug intolerance. The research provides valuable insights into the complexity of cisplatin resistance and metabolism, which can vary among different types of tumors. [Extracted from the article]