Researchers from Southern Medical University Report Details of New Studies and Findings in the Area of Hepatitis B Virus (Nedd4 Family Ubiquitin Ligase Aip4 Interacts With Alix To Enable Hbv Naked Capsid Egress In an Alix...).

New research from Southern Medical University in Guangzhou, China, explores the mechanism of hepatitis B virus (HBV) naked capsid egress. The study reveals that the K96 residue of the HBV core protein is critical for naked capsid egress, and intracellular egress-competent capsids are associated with ubiquitinated host proteins. The ESCRT-III-binding protein Alix and its Bro1 domain are required for naked capsid secretion, and the NEDD4 E3 ubiquitin ligase family member AIP4 stimulates the release of naked capsid. These findings provide new insights into the understanding of HBV naked capsid egress. [Extracted from the article]