Oxygen Gas-Filled Metal-Organic Frameworks (MOFs) Delivery System: A Hypothetical Design for Injectable Oxygen.

[Display omitted] • Exploring the unique properties and potential of Metal-Organic Frameworks (MOFs) as oxygen delivery systems. • Combining simulation and experimental approaches to design and evaluate MOFs as delivery systems for oxygen gas. • Discuss the benefits, challenges, and future directions of MOFs as an oxygen carrier in the medical field. Oxygen delivery systems are crucial in critical care medicine, particularly for managing acute respiratory distress. This study presents a novel approach, exploring the potential of Metal-Organic Frameworks (MOFs) as oxygen delivery systems. We highlight their unique properties and potential for enhancing oxygenation in medical settings. Understanding their biocompatibility, oxygen-carrying capacity, and controlled release mechanisms is pivotal for successful implementation in clinical practice. Thanks to their exceptional porosity, structural diversity, lower crystal density, and tunability, MOFs offer a fresh perspective on developing innovative oxygen carriers. We propose that MOFs will demonstrate biocompatibility, stability, and the ability to deliver oxygen in a controlled and sustained manner when administered intravenously in living organisms. Gas adsorption and molecular simulation techniques will demonstrate reversible oxygen binding within MOFs and predict controlled release kinetics. The findings of the simulations and experiments should indicate the feasibility of utilising MOFs as intravenous oxygen carriers with controlled and reversible oxygen release behaviour. [ABSTRACT FROM AUTHOR]