Research from University of Gothenburg Broadens Understanding of Rheumatoid Arthritis (Methotrexate promotes the release of granulocyte-macrophage colony-stimulating factor from rheumatoid arthritis fibroblast-like synoviocytes via autocrine...).

A recent study from the University of Gothenburg explores the impact of methotrexate on rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). The research found that methotrexate treatment can lead to the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) from RA-FLS through autocrine interleukin-1 signaling, potentially contributing to persistent synovitis. This study sheds light on the complex mechanisms underlying rheumatoid arthritis and the effects of methotrexate therapy. [Extracted from the article]