Exploring voltage-gated sodium channel conformations and protein-protein interactions using AlphaFold2.

The article discusses the importance of voltage-gated sodium (NaV) channels in regulating electrical activity in cells and their significance as therapeutic targets. It explores the use of AlphaFold2 to model different NaV channel conformations and protein interactions, such as with auxiliary {beta}-subunits and calmodulin. The study demonstrates the potential of deep learning-based methods to enhance understanding of NaV channel structure, gating, and modulation, with implications for future drug discovery efforts. [Extracted from the article]