Systemic inflammation accelerates neurodegeneration in a rat model of Parkinson's disease overexpressing human alpha-synuclein (Updated October 22, 2024).

The article discusses a study on a rat model of Parkinson's disease that overexpresses human alpha-synuclein and is exposed to a pro-inflammatory insult. The study found that the rats showed dopaminergic neuronal loss in the substantia nigra pars compacta and a reduction in dopamine release in the striatum after exposure to lipopolysaccharide. This research suggests that the interaction between alpha-synuclein and inflammation may contribute to neurodegeneration in Parkinson's disease. [Extracted from the article]