Inhibition of the RNA Regulator HuR mitigates spinal cord injury by potently suppressing post-injury neuroinflammation (Updated October 27, 2024).

The article discusses the role of neuroinflammation in promoting secondary tissue injury after spinal cord trauma. It highlights the potential of a small molecule inhibitor, SRI-42127, in suppressing neuroinflammation after spinal cord injury and improving functional outcomes in mice. The study found that SRI-42127 significantly attenuated loss of locomotor function, post-injury pain, reduced lesion size, neuronal loss, and increased myelin sparing, indicating its potential as a therapeutic approach for suppressing neuroinflammatory responses after tissue injury. [Extracted from the article]