Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway.

The article discusses how obesity can lead to changes in gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway. The study used tissue samples from patients with obesity, mice on a high-fat diet, and human cell cultures to investigate the mechanisms behind gastric emptying dysfunction in obese individuals. The findings suggest that obesity triggers a phenotypic switch in gastric smooth muscle cells, offering potential biomarkers for diagnosing stomach dysmotility in obese patients. [Extracted from the article]