Findings from Institute for Molecular Biotechnology Provide New Insights into Life Science (Lineage Tracing of shh Plus Floor Plate Cells and Dynamics of Dorsal-ventral Gene Expression In the Regenerating Axolotl Spinal Cord).

A study conducted at the Institute for Molecular Biotechnology in Vienna, Austria, focused on the regeneration of the spinal cord in axolotl salamanders. The research found that Shh+ cells, which are responsible for secreting tissue-patterning molecules, retain their floor plate identity during regeneration, serving as a stable cellular source for this signaling center in the axolotl spinal cord. The study utilized lineage tracing and mathematical modeling to quantify gene expression levels and floor plate size during regeneration. Financial support for the research was provided by various organizations including the European Research Council and the Austrian Science Fund. [Extracted from the article]