Inhibitors of lysinoalanine crosslinking in the flagella hook as antimicrobials against spirochetes (Updated November 4, 2024).

The article discusses the potential use of inhibitors of lysinoalanine crosslinking in the flagella hook as antimicrobials against spirochetes, which are invasive bacteria responsible for diseases like Lyme disease and syphilis. The study highlights the importance of lysinoalanine crosslinking in the motility of spirochetes and presents hexachlorophene and triclosan as potential inhibitors. These inhibitors have shown promise in reducing bacterial motility and could be used to combat spirochete-derived illnesses. The research is available as a preprint and has not yet been peer-reviewed. [Extracted from the article]