Studies from Department of Chemistry Have Provided New Information about Antiparasitic Agents (In Silico Screening of Fda-approved Anthelmintic Drugs Against Luxr Protein As Quorum-sensing Inhibitors and Exploration of Their Binding Mechanism...).

Researchers from the Department of Chemistry in West Bengal, India, have conducted a study on antiparasitic agents, focusing on the use of FDA-approved anthelmintic drugs as quorum-sensing inhibitors for bacterial infections caused by multidrug-resistant bacteria. The study identified seven drugs with strong binding affinity to the LuxR protein associated with the quorum-sensing mechanism of Staphylococcus aureus. Molecular dynamic simulations showed promising stability for the LuxR-Rafoxanide and LuxR-Fenbendazole complexes. This research has been peer-reviewed and provides valuable insights into potential alternatives to antibiotics for managing multidrug resistance. [Extracted from the article]