Researchers from University of Pittsburgh Report New Studies and Findings in the Area of Pain and Central Nervous System (Proinflammatory Microglial Activation Impairs In Vitro Cortical Tissue Repair Via Zinc-dependent Adam17 Cleavage of the...).

A recent study conducted by researchers at the University of Pittsburgh focused on the impact of proinflammatory microglial activation on tissue repair in the context of traumatic brain injury. The study found that proinflammatory activation impeded wound closure by upregulating the zinc-dependent ADAM17 enzyme, which cleaved the CSF-1 receptor, essential for astrocyte-mediated tissue repair. Inhibition of ADAM17 and zinc chelation were shown to promote tissue recovery, highlighting the role of ADAM17 in regulating tissue repair processes. This research was supported by the National Institutes of Health (NIH) and has been peer-reviewed. [Extracted from the article]