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GPER-1 Rapid Regulation Influences p-Akt Expression to Resist Stress-Induced Injuries in a Sex-Specific Manner.

Authors :
Lili SANG
Lu FU
Liping GAO
ADU-AMANKWAAH, Joseph
Zheng GONG
Tao LI
Ziyu MA
Zhaoting WANG
Jing XU
Hong SUN
Source :
Physiological Research; Oct2024, Vol. 73 Issue 5, p831-839, 9p
Publication Year :
2024

Abstract

G protein-coupled estrogen receptor 1 (GPER-1) has gained recognition for its role in conferring cardioprotection. However, the extent to which GPER-1 exerts equally important effects in both sexes remains unclear. The study found similar expressions of GPER-1 in rat heart apex in both sexes. In male rats, administering epinephrine (Epi) at a dose of 31.36 µg/100 g resulted in a rapid decline in cardiac function, accompanied by a sharp increase in bax/bcl-2 levels. In contrast, female rats did not display significant changes in cardiac function under the same conditions. Additionally, compared to the injection of Epi alone (at a dose of 15.68 µg/100 g), the administration of G15 (GPER-1 antagonist) further decreased cardiac function in both male and female rats. However, it only increased mortality and lung coefficient in male rats. Conversely, G1 (GPER-1 agonist) administration improved cardiac function in both sexes. Notably, the apex of the male heart exhibited lower levels of inhibitory G protein (Gai). Furthermore, female and male rats treated with Epi displayed elevated phosphorylated protein kinase B (p-Akt). Compared to their respective Epi groups, the administration of G15 increased p-Akt levels in female rat hearts but decreased them in male rat hearts. Conversely, the administration of G1 decreased p-Akt levels in females but rapidly increased them in male rats. Our study uncovers the vital role of GPER-1 in protecting against stress-induced heart injuries in a sex-specific manner. These findings hold immense potential for advancing targeted cardiac therapies and enhancing outcomes for both females and males. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08628408
Volume :
73
Issue :
5
Database :
Supplemental Index
Journal :
Physiological Research
Publication Type :
Academic Journal
Accession number :
181081963
Full Text :
https://doi.org/10.33549/physiolres.935176