Heterogeneous endocrine cell composition defines human islet functional phenotypes.

The article discusses a study on the composition of endocrine cells in human islets and its impact on insulin secretion, genetic risk for type 2 diabetes, and personalized medicine. The research, based on data from organ donors without diabetes, reveals significant heterogeneity in islet cell composition related to various factors such as hormone secretory traits, sex, race, ancestry, and genetic risk for diabetes. The findings suggest implications for understanding diabetes heterogeneity, islet dysfunction, and potential strategies for personalized medicine and beta cell replacement therapy. [Extracted from the article]