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PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations.
- Source :
- Gene Therapy Weekly; 12/17/2024, p614-614, 1p
- Publication Year :
- 2024
-
Abstract
- The article discusses the role of PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformations (AVMs). It highlights the findings that pharmacological PIEZO1 inhibition and genetic Piezo1 deletion effectively mitigated AVM formation in Alk1-deficient mice. The study provides new insights into the mechanistic underpinnings of ALK1-related vascular diseases and identifies potential therapeutic targets to prevent AVMs. [Extracted from the article]
Details
- Language :
- English
- ISSN :
- 10782842
- Database :
- Supplemental Index
- Journal :
- Gene Therapy Weekly
- Publication Type :
- Periodical
- Accession number :
- 181613674