Pharmacological concentrations of vitamin C inhibit hypochlorous acid generation by myeloperoxidase, and oxidized vitamin C inhibits critical thiol proteins and growth of Jurkat cells.

A recent preprint abstract suggests that vitamin C at millimolar concentrations can inhibit the generation of hypochlorous acid by myeloperoxidase, impacting the growth and viability of Jurkat cells. The oxidation products of vitamin C interact with specific thiol proteins, indicating potential implications for cancer treatment and diseases related to neutrophil activation. The study highlights the importance of maintaining pharmacological levels of vitamin C in the bloodstream for beneficial effects, potentially through oxidation facilitation treatments. [Extracted from the article]