Prior infection with IBDV prolonged the shedding of a mallard H3N8 influenza A virus (IAV) challenge from the oropharyngeal cavity of some chickens and increased the number of amino acid substitutions in the IAV samples.

The article discusses how prior infection with Infectious Bursal Disease Virus (IBDV) in chickens can impact their susceptibility to Influenza A Virus (IAV) from aquatic waterfowl reservoirs. The study found that chickens with a history of IBDV infection had prolonged shedding of IAV from the oropharyngeal cavity, increased amino acid substitutions in the IAV samples, and altered IAV intra-host evolution. This research sheds light on the interactions between different viruses in poultry and their implications for viral evolution and transmission. [Extracted from the article]