Study finds strategies to minimize acne recurrence after taking medication for severe acne.

A study conducted by researchers at Mass General Brigham found that approximately 1-in-5 patients experience acne recurrence after taking isotretinoin for severe acne, with females and those who had taken lower cumulative dosages being at higher risk. The study, published in JAMA Dermatology, suggests that dosing regimens could be individualized based on patient goals and preferences, as both lower and higher daily dose regimens can be effective as long as a sufficient cumulative dose is reached. The researchers also found that greater cumulative isotretinoin dose was associated with reduced acne recurrence, but not beyond 220mg/kg. [Extracted from the article]