Rescue of hippocampal synaptic plasticity and memory performance by Fingolimod (FTY720) in APP/PS1 model of Alzheimer's disease is accompanied by correction in metabolism of sphingolipids, polyamines, and phospholipid saturation composition.

A study published in Health & Medicine Week discusses the potential therapeutic effects of Fingolimod (FTY720) in Alzheimer's disease. The research suggests that FTY720 may improve synaptic plasticity and memory in mice with Alzheimer's by correcting metabolic imbalances in sphingolipids, polyamines, and phospholipids. The study highlights the importance of rebalancing these pathways to promote mitochondrial function, synaptic plasticity, and reduce inflammation in Alzheimer's disease. This preprint has not yet undergone peer review. [Extracted from the article]