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Enhancement of Antiangiogenic Effects of Human Canstatin with a Hypoxia-Regulated Transgene Vector in Lung Cancer Model.
- Source :
- Cancer Journal; Mar/Apr2006, Vol. 12 Issue 2, p136-146, 11p
- Publication Year :
- 2006
-
Abstract
- Canstatin, a newly identified antiangiogenesis protein, has a potent inhibitory effect on the proliferation and growth of endothelial cells. To enhance the expression and antiangiogenic effects of canstatin in solid tumors, we constructed a eukaryotic expression vector that encodes human canstatin cDNA downstream from nine copies of the hypoxia-response element. [ABSTRACT FROM AUTHOR]
- Subjects :
- CANCER
CANCER cells
CANCER treatment
HYPOXEMIA
CYSTS (Pathology)
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 15289117
- Volume :
- 12
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Cancer Journal
- Publication Type :
- Academic Journal
- Accession number :
- 20708153