Enhancement of Antiangiogenic Effects of Human Canstatin with a Hypoxia-Regulated Transgene Vector in Lung Cancer Model.

Canstatin, a newly identified antiangiogenesis protein, has a potent inhibitory effect on the proliferation and growth of endothelial cells. To enhance the expression and antiangiogenic effects of canstatin in solid tumors, we constructed a eukaryotic expression vector that encodes human canstatin cDNA downstream from nine copies of the hypoxia-response element. [ABSTRACT FROM AUTHOR]