SUMOylation and PPARγ: Wrestling with inflammatory signaling.

The molecular mechanisms whereby PPARγ inhibits inflammatory gene expression in macrophages are poorly understood. In a recent Nature paper, provide a new model for trans-repression in which ligand-dependent SUMOylation of PPARγ results in its recruitment to the promoters of inflammatory genes where it inhibits transcription by preventing clearance of corepressor complexes. [Copyright &y& Elsevier]