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The prognosis of patients with local recurrence more than five years after breast conservation therapy for invasive breast carcinoma.
- Source :
- European Journal of Surgical Oncology; Feb2006, Vol. 32 Issue 1, p34-38, 5p
- Publication Year :
- 2006
-
Abstract
- Abstract: Aims: The increasing use of breast-conserving therapy (BCT) and the rising incidence and improved prognosis of early breast are causing a substantial increase in the absolute number of patients with a late local recurrence following BCT. This study examined the characteristics and the prognosis of patients with a local recurrence occurring more than 5 years after BCT. Methods: In the period 1982–1997, 3280 patients with invasive breast cancer underwent breast-conserving therapy in one of the eight community hospitals in the South-eastern part of The Netherlands. Of these patients, 98 developed a local recurrence in the breast more than 5 years after BCT. Results: Eighty-five of the 98 recurrences were invasive, 12 were purely in situ and for one patient this information was not available. The 5 years distant recurrence-free survival rate of 85 patients with a late invasive local recurrence was 68% (95% confidence interval [CI], 56–80) and significantly better than the rate of 41% (95% CI, 33–48) in an existing cohort of 173 patients with invasive recurrence within 5 years after BCT (p=0.007). Local excision of the recurrence was followed by a significantly lower local control rate than salvage mastectomy (50 vs 89%; p=0.004). Conclusion: The prognosis of patients with a local recurrence more than 5 years after BCT is significantly better than of patients with local recurrence within 5 years after BCT. [Copyright &y& Elsevier]
- Subjects :
- CANCER patients
BREAST cancer
DIAGNOSIS
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 07487983
- Volume :
- 32
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- European Journal of Surgical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21621577
- Full Text :
- https://doi.org/10.1016/j.ejso.2005.10.005