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αvβ3-dependent cross-presentation of matrix metalloproteinase--2 by melanoma cells gives rise to a new tumor antigen.
- Source :
- Journal of Experimental Medicine; 7/4/2005, Vol. 202 Issue 1, p61-72, 12p, 1 Diagram, 2 Charts, 6 Graphs
- Publication Year :
- 2005
-
Abstract
- A large array of antigens that are recognized by tumor-specific T cells has been identified and shown to be generated through various processes. We describe a new mechanism underlying T cell recognition of melanoma cells, which involves the generation of a major histocompatibility complex class I--restricted epitope after tumor-mediated uptake and processing of an extracellular protein--a process referred to as cross-presentation--which is believed to be restricted to immune cells. We show that melanoma cells cross-present, in an αvβ3-dependent manner, an antigen derived from secreted matrix metalloproteinase-2 (MMP-2) to human leukocyte antigen A*0201-restricted T cells. Because MMP-2 activity is critical for melanoma progression, the MMP-2 peptide should be cross-presented by most progressing melanomas and represents a unique antigen for vaccine therapy of these tumors. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221007
- Volume :
- 202
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Journal of Experimental Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26928113
- Full Text :
- https://doi.org/10.1084/jem.20042138