Epilepsy, Brain Injury and Cell Death.

Mesial temporal lobe epilepsy (TLE) represents the most frequent type of focal epilepsies. The most prominent neuropathological characteristics of TLE are severe neurodegenerations in the hippocampus (termed Ammon's horn sclerosis) and in related brain areas such as the amygdala and entorhinal cortex. Within the hippocampus, pyramidal cells of the areas CA1 and CA3 and interneurons of the dentate hilus are most vulnerable, whereas granule cells of the dentate gyrus, CA2 pyramidal cells and the subiculum are comparatively preserved. [ABSTRACT FROM AUTHOR]