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HSV Vectors for Gene Therapy.
- Source :
- Herpes Simplex Virus Protocols; 1998, p369-386, 18p
- Publication Year :
- 1998
-
Abstract
- A number of aspects of the natural biology of herpes simplex virus (HSV) make it an attractive candidate for a vector to express foreign genes within the nervous system. Some of the advantages of an HSV vector are 1Establishment of a life-long latent infection within peripheral and central nervous system neurons (for a review, see ref,1);2Latent HSV genomes exist as multiple episomal copies/neuron and integration is not known to occur (2), and3.Nonreplicating HSV recombinants can establish a latent infection efficiently (3) [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9780896033474
- Database :
- Supplemental Index
- Journal :
- Herpes Simplex Virus Protocols
- Publication Type :
- Book
- Accession number :
- 33153176
- Full Text :
- https://doi.org/10.1385/0-89603-347-3:369