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Parametric Linkage Analysis.
- Source :
- Quantitative Trait Loci; 2002, p13-35, 23p
- Publication Year :
- 2002
-
Abstract
- "Linkage" describes the situation in which two syntenic loci are inherited together. More specifically, two loci are said to be linked if they are close enough to each other on a chromosome that recombination during meiosis is uncommon enough for their cosegregation to be detectable within families. Thus, linkage is a property of loci. All linkage techniques are essentially designed to test for a statistical association between a marker (genetic or biochemical) and a phenotypic trait. Classical model-based (parametric) linkage analysis was developed to investigate the cosegregation of a genetic marker and a binary trait (generally, disease affection status) within pedigrees. Model-based linkage analysis of quantitative traits is also possible and forms the basis of this chapter. Methods based on the exact likelihood calculation are described in this chapter; Markov chain Monte Carlo methods are described in Chapter 6. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISBNs :
- 9780896039278
- Database :
- Supplemental Index
- Journal :
- Quantitative Trait Loci
- Publication Type :
- Book
- Accession number :
- 33418177
- Full Text :
- https://doi.org/10.1385/1-59259-176-0:013